iPost: Cognitive speed, working memory and TBI

The Nature of Processing Speed Deficits in Traumatic Brain Injury: is Less Brain More?

Journal	Brain Imaging and Behavior
Publisher	Springer New York
ISSN	1931-7557 (Print) 1931-7565 (Online)
Issue	Volume 4, Number 2 / June, 2010
DOI	10.1007/s11682-010-9094-z
Pages	141-154
Subject Collection	Behavioral Science
SpringerLink Date	Saturday, May 01, 2010

Frank G. Hillary^{1, 2, 6} , Helen M. Genova³, John D. Medaglia¹, Neal M. Fitzpatrick⁴, Kathy S. Chiou¹, Britney M. Wardecker¹, Robert G. Franklin Jr.¹, Jianli Wang⁴ and John DeLuca^{3, 5}

The cognitive constructs working memory (WM) and processing speed are fundamental components to general intellectual functioning in humans and highly susceptible to disruption following neurological insult. Much of the work to date examining speeded working memory deficits in clinical samples using functional imaging has demonstrated recruitment of network areas including prefrontal cortex (PFC) and anterior cingulate cortex (ACC). What remains unclear is the nature of this neural recruitment. The goal of this study was to isolate the neural networks distinct from those evident in healthy adults and to determine if reaction time (RT) reliably predicts observable between-group differences. The current data indicate that much of the neural recruitment in TBI during a speeded visual scanning task is positively correlated with RT. These data indicate that recruitment in PFC during tasks of rapid information processing are at least partially attributable to normal recruitment of PFC support resources during slowed task processing.

Electronic supplementary material  The online version of this article (doi:10.1007/s11682-010-9094-z) contains supplementary material, which is available to authorized users.

Keywords  TBI - fMRI - Reorganization - Working memory - Processing speed

Sent from KMcGrew iPhone (IQMobile). (If message includes an image-double click on it to make larger-if hard to see)